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Impact of Apolipoprotein E4 Polymorphism on the Gray Matter Volume and the White Matter Integrity in Subjective Memory Impairment without White Matter Hyperintensities: Voxel‐Based Morphometry and Tract‐Based Spatial Statistics Study under 3‐Tesla MRI
Author(s) -
Lee YoungMin,
Ha JiKyung,
Park JeMin,
Lee ByungDae,
Moon EunSoo,
Chung YoungIn,
Kim JiHoon,
Kim HakJin,
Mun ChiWoong,
Kim TaeHyung,
Kim YoungHoon
Publication year - 2015
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12207
Subject(s) - white matter , cingulum (brain) , fractional anisotropy , medicine , corpus callosum , apolipoprotein e , hyperintensity , diffusion mri , atrophy , splenium , leukoaraiosis , voxel based morphometry , magnetic resonance imaging , pathology , radiology , disease
OBJECTIVE The aim of this study is to compare gray matter (GM) volume and white matter (WM) integrity in Apolipoprotein E4 (ApoE ε4) carriers with that of ApoE ε4 noncarriers using the voxel‐based morphometry and diffusion tensor imaging (DTI) to investigate the effect of the ApoE ε4 on brain structures in subjective memory impairment (SMI) without white matter hyperintensities (WMH). METHODS Altogether, 26 participants with SMI without WMH were finally recruited from the Memory impairment clinics of Pusan National University Hospital in Korea. All participants were ApoE genotyped (ApoE ε4 carriers: n = 13, matched ApoE ε4 noncarriers: n = 13) and underwent 3‐tesla magnetic resonance imaging (MRI) including 3‐dimensional volumetric images for GM volume and DTI for WM integrity. RESULTS ApoE ε4 carriers compared with noncarriers in SMI without WMH showed the atrophy of GM in inferior temporal gyrus, inferior parietal lobule, anterior cingulum, middle frontal gyrus, and precentral gyrus and significantly lower fractional anisotropy WM values in the splenium of corpus callosum and anterior corona radiate. CONCLUSION Our findings suggest that the ApoE ε4 is associated with both atrophy of GM volume and disruption of WM integrity in SMI without WMH.