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Central Aortic Pressure and Pulsatility Index in Acute Ischemic Stroke
Author(s) -
Kim Jeong Yeon,
Bushnell Cheryl D.,
Park Joong Hyun,
Han Seung Min,
Im Jin Hee,
Han Sang Won,
Baik Jong Sam,
Park Jae Hyeon
Publication year - 2014
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12151
Subject(s) - medicine , cardiology , pulse pressure , aortic pressure , transcranial doppler , pulsatile flow , blood pressure , peripheral , stroke (engine) , middle cerebral artery , basilar artery , ischemia , mechanical engineering , engineering
BACKGROUND AND PURPOSE We investigated the relationship between transcranial Doppler (TCD) pulsatility index (PI) and central aortic pressure by measurement of the aortic augmentation index (AIx). METHODS We enrolled 148 consecutive patients with a diagnosis of acute ischemic stroke. Patients were eligible for the study if they experienced their first ischemic stroke within the preceding 7 days and were 45 years of age or older. At Day 7 (±2) after stroke onset, TCD studies were performed and AIx was measured by applanation tonometry on the same days. RESULTS The mean age was 66.3 (47–90) years and 37.8% were women. The mean middle cerebral artery (MCA) PI was significantly related with age ( r =.361), hypertension ( r = .184), peripheral systolic blood pressure (SBP; r = .211), peripheral pulse pressure (PP; r = .396), aortic SBP ( r = .184), aortic DBP ( r = –.181), and aortic PP ( r = .371). The basilar artery (BA) PI was significantly related with age ( r = .311), peripheral DBP ( r = –.267), peripheral PP ( r = .358), aortic DBP ( r = –.266), and aortic PP ( r = .347). CONCLUSIONS TCD PI was significantly related with central aortic pressure, especially PP. The PI in the MCA and BA is closely associated with the pulsatile component of BP in the systemic circulation.