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Hippocampal Surface Deformation Accuracy in T1‐Weighted Volumetric MRI Sequences in Subjects with Epilepsy
Author(s) -
Hogan R. Edward,
Moseley Emily D.,
Maccotta Luigi
Publication year - 2014
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12135
Subject(s) - hippocampal formation , magnetic resonance imaging , medicine , nuclear medicine , epilepsy , segmentation , sørensen–dice coefficient , fractional anisotropy , nuclear magnetic resonance , diffusion mri , artificial intelligence , radiology , image segmentation , computer science , physics , psychiatry
BACKGROUND AND PURPOSE To demonstrate the accuracy across different acquisition and analysis methods, we evaluated the variability in hippocampal volumetric and surface displacement measurements resulting from two different MRI (magnetic resonance imaging) acquisition protocols. METHODS Nine epilepsy patients underwent two independent T1‐weighted magnetization prepared spoiled gradient sequences during a single 3T MRI session. Using high‐dimension mapping‐large deformation (HDM‐LD) segmentation, we calculated volumetric estimates and generated a vector‐based 3‐dimensional surface model of each subject's hippocampi, and evaluated volume and surface changes, the latter using a cluster‐based noise estimation model. RESULTS Mean hippocampal volumes and standard deviations for the left hippocampi were 2,750 (826) mm 3 and 2,782 (859) mm 3 ( P = .13), and for the right hippocampi were 2,558 (750) mm 3 and 2,547 (692) mm 3 ( P = .76), respectively for the MPR1 and MPR2 sequences. Average Dice coefficient comparing overlap for segmentations was 86%. There was no significant effect of MRI sequence on volume estimates and no significant hippocampal surface change between sequences. CONCLUSION Statistical comparison of hippocampal volumes and statistically thresholded HDM‐LD surfaces in TLE patients showed no differences between the segmentations obtained in the two MRI acquisition sequences. This validates the robustness across MRI sequences of the HDM‐LD technique for estimating volume and surface changes in subjects with epilepsy.