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Lithium Toxicity and PRES: A Novel Association
Author(s) -
Fitzgerald Ryan T.,
Fitzgerald Caris T.,
Samant Rohan S.,
Kumar Manoj,
Ramakrishniah Raghu,
Hemert Rudy,
Angtuaco Edgardo J.
Publication year - 2014
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12094
Subject(s) - medicine , posterior reversible encephalopathy syndrome , lithium (medication) , toxicity , pathogenesis , hypertensive encephalopathy , toxic encephalopathy , encephalopathy , pharmacology , bioinformatics , magnetic resonance imaging , biology , blood pressure , radiology
We report two cases of posterior reversible encephalopathy syndrome (PRES) occurring in association with supra‐therapeutic serum lithium levels. Although the neurologic manifestations of lithium toxicity are well known, this is, to our knowledge, the first report describing a link between lithium toxicity and PRES. We discuss the current understanding of the pathogenesis of PRES and suggest mechanisms by which lithium may play a role in its development.