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Establishing Magnetic Resonance Images Orientation for the EADC‐ADNI Manual Hippocampal Segmentation Protocol
Author(s) -
Boccardi Marina,
Bocchetta Martina,
Apostolova Liana G.,
Preboske Gregory,
Robitaille Nicolas,
Pasqualetti Patrizio,
Collins Louis D.,
Duchesne Simon,
Jack Clifford R.,
Frisoni Giovanni B.
Publication year - 2013
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12065
Subject(s) - hippocampal formation , orientation (vector space) , magnetic resonance imaging , segmentation , medicine , artificial intelligence , similarity (geometry) , pattern recognition (psychology) , reliability (semiconductor) , nuclear medicine , computer science , computer vision , radiology , mathematics , power (physics) , physics , geometry , quantum mechanics , image (mathematics)
BACKGROUND AND PURPOSE An effort to define and validate a Harmonized Protocol for standard hippocampal segmentation is being carried out. We wished to estimate the effect of magnetic resonance image (MRI) spatial orientation on manual hippocampal segmentations to define optimal standard orientation of MRIs for hippocampal volumetry. METHODS Three expert tracers segmented twice the hippocampi of 10 ADNI subjects on MRI slices oriented perpendicular to the anterior‐posterior commissure (AC‐PC) line and the long hippocampal axes plane, following internationally harmonized landmarks. We computed intra and interrater reliability figures for total volumes and similarity coefficients. RESULTS Total volume reliability was similar for both orientations. Similarity coefficients were significantly higher for the AC‐PC orientation (exact P = 0.002). DISCUSSION These data show that AC‐PC orientation is slightly more reliable for manual segmentations, possibly due to better visualization of the cerebrospinal fluid spaces separating hippocampal head and amygdala. A Delphi panel of experts has used these data to decide on the optimal orientation for a Harmonized Protocol for hippocampal segmentation.