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Voxel‐Wise Co‐analysis of Macro‐ and Microstructural Brain Alteration in Mild Cognitive Impairment and Alzheimer's Disease Using Anatomical and Diffusion MRI
Author(s) -
Cardenas Valerie A.,
Tosun Duygu,
Chao Linda L.,
Fletcher P. Thomas,
Joshi Sarang,
Weiner Michael W.,
Schuff Norbert
Publication year - 2013
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12002
Subject(s) - corpus callosum , diffusion mri , voxel , medicine , voxel based morphometry , posterior cingulate , fractional anisotropy , magnetic resonance imaging , statistical parametric mapping , temporal lobe , neuroscience , functional magnetic resonance imaging , psychology , radiology , pathology , white matter , psychiatry , epilepsy
BACKGROUND AND PURPOSE To determine if a voxel‐wise “co‐analysis” of structural and diffusion tensor magnetic resonance imaging (MRI) together reveals additional brain regions affected in mild cognitive impairment (MCI) and Alzheimer's disease (AD) than voxel‐wise analysis of the individual MRI modalities alone. METHODS Twenty‐one patients with MCI, 21 patients with AD, and 21 cognitively normal healthy elderly were studied with MRI. Maps of deformation and fractional anisotropy (FA) were computed and used as dependent variables in univariate and multivariate statistical models. RESULTS Univariate voxel‐wise analysis of macrostructural changes in MCI showed atrophy in the right anterior temporal lobe, left posterior parietal/precuneus region, WM adjacent to the cingulate gyrus, and dorsolateral prefrontal regions, consistent with prior research. Univariate voxel‐wise analysis of microstructural changes in MCI showed reduced FA in the left posterior parietal region extending into the corpus callosum, consistent with previous work. The multivariate analysis, which provides more information than univariate tests when structural and FA measures are correlated, revealed additional MCI‐related changes in corpus callosum and temporal lobe. CONCLUSION These results suggest that in corpus callosum and temporal regions macro‐ and microstructural variations in MCI can be congruent, providing potentially new insight into the mechanisms of brain tissue degeneration.