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Innate immunity, inflammation and tumour progression: double‐edged swords
Author(s) -
Mantovani A.,
Ponzetta A.,
Inforzato A.,
Jaillon S.
Publication year - 2019
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/joim.12886
Subject(s) - innate immune system , inflammation , immunology , macrophage , innate lymphoid cell , immunity , immune system , medicine , myeloid cells , cancer research , biology , biochemistry , in vitro
Components of the cellular and the humoral arm of the immune system are essential elements of the tumour microenvironment ( TME ). The TME includes tumour‐associated macrophages which have served as a paradigm for the cancer‐promoting inflammation. Cytokines, IL ‐1 in particular, and complement have emerged as important players in tumour promotion. On the other hand, myeloid cells, innate lymphoid cells and complement have the potential, if unleashed, to mediate anticancer resistance. Targeting checkpoints restraining innate immunity, macrophages and natural killer (NK) cells in particular holds promise as a therapeutic strategy.