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Vasopressin and metabolic disorders: translation from experimental models to clinical use
Author(s) -
Nakamura K.,
Velho G.,
Bouby N.
Publication year - 2017
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/joim.12649
Subject(s) - vasopressin , endocrinology , medicine , glucose homeostasis , homeostasis , energy homeostasis , vasopressin receptor , receptor , arginine vasopressin receptor 2 , hormone , diabetes mellitus , insulin resistance , antagonist
Abstract Vasopressin has many physiological actions in addition to its well‐defined role in the control of fluid homeostasis and urine concentration. An increasing body of evidence suggests that the vasopressin–hydration axis plays a role in glucose homeostasis. This review summarizes the knowledge accumulated over the last decades about the influence of vasopressin in the short‐term regulation of glycaemia. It describes the possible role of this hormone through activation of V1a and V1b receptors on liver and pancreas functions and on the hypothalamic–pituitary–adrenal axis. Moreover, we report recent in vivo studies demonstrating the role of vasopressin in the long‐term regulation of glycaemia. Indeed, V1a‐ or double‐V1aV1b‐receptor knockout mice display significant changes in the glucose and lipid metabolism. In rats, sustained high V1aR activation increases basal glycaemia and aggravates glucose intolerance in obese rats. Finally, the translation from animal findings to human was evidenced by epidemiological and genetic studies that showed that high vasopressin level is a risk factor for hyperglycaemia, metabolic disorders and diabetes.