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Calcium signalling and ER stress in insulin resistance and atherosclerosis
Author(s) -
Ozcan L.,
Tabas I.
Publication year - 2016
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/joim.12562
Subject(s) - endoplasmic reticulum , insulin resistance , medicine , unfolded protein response , pathogenesis , calcium signaling , calcium , disease , downregulation and upregulation , bioinformatics , diabetes mellitus , microbiology and biotechnology , endocrinology , biology , gene , genetics
The burden of type 2 diabetes and its major complication cardiovascular disease is rapidly increasing worldwide. Understanding the underlying pathogenic mechanisms of these diseases is crucial to develop novel therapeutics. Recent work using genetic and biochemical methods in mouse models and human samples have identified disturbed calcium signalling and endoplasmic reticulum stress as emerging factors involved in the pathogenesis of many metabolic diseases. In this review, we will highlight the specific roles of calcium signalling and endoplasmic reticulum stress response in the development of insulin resistance and atherosclerosis.