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Nucleic acid sensing and beyond: virtues and vices of high‐mobility group box 1
Author(s) -
Yanai H.,
Taniguchi T.
Publication year - 2014
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/joim.12285
Subject(s) - nucleic acid , medicine , high mobility group , group (periodic table) , biochemistry , biology , gene , chemistry , organic chemistry
Abstract High‐mobility group box 1 ( HMGB 1) was first described as an architectural chromatin‐binding protein. Today, a wealth of evidence indicates that this protein is very versatile and serves an amazing assortment of roles in the nucleus, cytoplasm and extracellular milieu. As a result, HMGB 1 is fast becoming recognized as a key regulator of protective and pathological immune responses. Whilst acknowledging the many functions of HMGB 1 and its family members, we focus this review on their role as broad effectors of immune responses mediated by nucleic acids. In addition, we touch upon the recent progress in determining the in vivo role of HMGB 1 as revealed by the study of mice conditionally null for the Hmgb1 gene.