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Application of routine electronic health record databases for pharmacogenetic research
Author(s) -
Yasmina A.,
Deneer V. H. M.,
Maitlandvan der Zee A. H.,
Staa T. P.,
Boer A.,
Klungel O.H.
Publication year - 2014
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/joim.12226
Subject(s) - medicine , electronic health record , pharmacogenetics , medline , health records , database , health care , genotype , genetics , biology , gene , political science , computer science , law , economics , economic growth
Inter‐individual variability in drug responses is a common problem in pharmacotherapy. Several factors (non‐genetic and genetic) influence drug responses in patients. When aiming to obtain an optimal benefit–risk ratio of medicines and with the emergence of genotyping technology, pharmacogenetic studies are important for providing recommendations on drug treatments. Advances in electronic healthcare information systems can contribute to increasing the quality and efficiency of such studies. This review describes the definition of pharmacogenetics, gene selection and study design for pharmacogenetic research. It also summarizes the potential of linking pharmacoepidemiology and pharmacogenetics (along with its strengths and limitations) and provides examples of pharmacogenetic studies utilizing electronic health record databases.