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Use of serotonin reuptake inhibitors in patients with psoriasis is associated with a decreased need for systemic psoriasis treatment: a population‐based cohort study
Author(s) -
Thorslund K.,
Svensson T.,
Nordlind K.,
Ekbom A.,
Fored C. M.
Publication year - 2013
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/joim.12093
Subject(s) - psoriasis , medicine , population , odds ratio , cohort , cohort study , confidence interval , dermatology , environmental health
Objective To investigate whether psoriasis is affected by the use of serotonin reuptake inhibitors ( SSRI s). Design A population‐based cohort study. Setting The general adult population with plaque psoriasis in Sweden between 1997 and 2006. Subjects A total of 69 830 patients with plaque psoriasis were identified in the National Patient Register. Whether study subjects were exposed to SSRI s was identified through the Swedish Prescribed Drug Register. The SSRI ‐exposed subjects ( n = 1282) had a prescription for SSRI s dispensed twice during 6 months at a Swedish pharmacy between 1 July 2006 and 1 April 2008, with a wash‐out period of 1 year or longer. The reference subjects ( n = 1282), who were not exposed to SSRI s, were matched for age, county of residence, sex, psoriasis severity and seasonal variation. Main outcome measure Change in psoriasis severity defined by switching between nonsystemic and systemic psoriasis treatments 6 months after exposure to SSRI s. Results The risk of switching from nonsystemic to systemic psoriasis treatments was significantly decreased in the SSRI ‐exposed group (odds ratio 0.44, 95% confidence interval 0.28–0.68). Conclusion SSRI use in patients with psoriasis is associated with a decreased need for systemic psoriasis treatment.