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Cord Blood Immunoglobulin M and Perinatal Outcome
Author(s) -
Legge Michael,
Evans Karen,
Martin Frances
Publication year - 1985
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/jog.1985.11.4.593
Subject(s) - cord blood , medicine , umbilical cord , cord , gestational age , birth weight , immunoglobulin m , obstetrics , pregnancy , rash , antibody , physiology , immunoglobulin g , gastroenterology , pediatrics , immunology , surgery , biology , genetics
Cord blood immunoglobulin M (IgM) and immunoglobulin A (IgA) levels were measured in 323 consecutive newborn infants with gestational ages ranging from 36–41 weeks. Seven of the samples (2.2%) were classified as being contaminated with maternal blood. Of the remaining 316 samples no significant difference could be demonstrated between sex (P > 0.05) or race (P > 0.05). There was no correlation with birth weight (r=0.084) or with advancing gestational age (P > 0.05) for each gestational group. Using a 95th percentile cut‐off limit of 23 mg/dl, 18 infants (5.7%) had elevated cord blood IgM levels. Fourteen of these infants had IgM levels below 30 mg/dl and demonstrated no evidence of infection. Four infants had IgM levels greater than 30 mg/dl. One infant had a rash and vomiting, one had no detectable abnormality and two had imperforate anuses. Fifteen infants (4.8%) demonstrated varying degrees of perinatal morbidity, none of these had elevated cord blood IgM levels. No evidence of infection was detected in any of the infants in this series.