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The Biologic Role of Sex Steroid Receptors in the Decidualization of Human Endometrium
Author(s) -
Tamaya Teruhiko,
Fujimoto Jiro,
Arabori Kenji,
Wada Keisuke,
Kato Yoshiko,
Okada Hiroji
Publication year - 1985
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/jog.1985.11.4.573
Subject(s) - decidualization , decidua , endocrinology , medicine , estrogen , estrogen receptor , endometrium , receptor , stromal cell , progesterone receptor , decidual cells , androgen receptor , biology , sex hormone receptor , estrogen receptor beta , chemistry , placenta , pregnancy , fetus , genetics , cancer , breast cancer , prostate cancer
This study was designed to elucidate the action of steroids in decidualization of stromal cells by a study of steroid receptor interaction in the human uterine endometrium. Dispersed endometrial stroma cells were found to contain receptor for estrogen (ER), progesterone (PR) and androgen (AR). Dissected uterine and ovarian arteries contained cytosol ER, and AR, but not PR. Human pregnant uterine decidua contained ER, PR and AR, whose levels did not seem to alter remarkably with advance of gestation during the first trimester. In cultured endometrial fibroblasts, the same three receptors were detected; estrogen stimulated synthesis of all steroid receptors, but progesterone with estrogen did not. These findings suggest that estrogen stimulates steroid receptor synthesis in mesenchymal fibroblasts around the uterine spiral arteries, and that progesterone and estrogen via their receptors cause differentiation of fibroblasts to decidual cells, in which steroid receptors are active during pregnancy.