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Histopathological examination of the curettage material in nonviable pregnancies and evaluation of the frequency of hydatidiform mole
Author(s) -
Dagdeviren Gulsah,
Cevher Funda,
Cendek Busra,
Erkaya Salim
Publication year - 2021
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.14867
Subject(s) - pregnancy , medicine , molar pregnancy , obstetrics , gestation , gestational age , gestational sac , gynecology , curettage , radiology , biology , genetics
Aim The study aimed to determine the frequency of possible missed diagnosis of gestational trophoblastic disease in nonviable pregnancies and to evaluate the importance of histopathological examination. Methods In this retrospective study, the results of the histopathological assessment of patients undergoing uterine surgery with a diagnosis of nonviable pregnancy were analyzed before 14 weeks of gestation. Nonviable pregnancy was defined as anembryonic pregnancy and intrauterine exitus (IU‐ex) based on ultrasound findings. The frequency and sonographic characteristics of molar pregnancy in nonviable pregnancy were analyzed. Results Molar pregnancy was detected in 24 (1.62%) of 1481 patients diagnosed with nonviable pregnancy on ultrasound. One thousand one hundred and twenty‐one of the cases were IU‐ex (75.69%) and the remaining were anembryonic pregnancy (24.31%). The mean crown‐rump length of pregnancies in the IU‐ex group was 16.7 mm and the mean gestational age was 8 weeks. The average gestational sac diameter was found to be 26 mm in anembryonic pregnancy patients. The hydatidiform mole ratio was significantly higher in anembryonic pregnancy patients (3.06%) than in IU‐ex patients (1.16%) ( p = 0.013). Conclusions The appearance of early molar pregnancy on ultrasound evaluation may mimic anembryonic pregnancies. Therefore, histopathological examination of anembryonic pregnancies may be useful in early diagnosis and for the treatment of gestational trophoblastic neoplasia.