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A case of synchronous high‐grade cervical intraepithelial neoplasia and metastatic squamous cell carcinomas of unknown primary in rectum
Author(s) -
Orisaka Syunsuke,
Nakamura Mitsuhiro,
Obata Takeshi,
Iwadare Junpei,
Mizumoto Yasunari,
Fujiwara Hiroshi
Publication year - 2021
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.14798
Subject(s) - rectum , medicine , biopsy , cervix , pathology , intraepithelial neoplasia , magnetic resonance imaging , pathological , oncology , radiology , prostate , gastroenterology , cancer
We report a case of synchronous high‐grade cervical intraepithelial neoplasia (CIN) and metastatic squamous cell carcinomas (SCCs) of unknown primary in the rectum. A 74‐year‐old woman was diagnosed with CIN3 by biopsy of the uterine cervix. Magnetic resonance imaging showed two masses in the outer rectal wall. They were diagnosed as SCCs by transrectal biopsy from one mass. On surgical treatment, CIN3 and SCCs in the rectum were identified, respectively. Pathological analysis revealed that SCCs were observed in serosa of the rectum, not mucosa, indicating that these tumors were metastatic SCCs. Gene analysis showed HPV31‐positive and TP53 mutation in CIN3, and HPV16‐positive in rectal SCCs. Pretreatment examination did not detect the primary site of metastatic SCCs in the rectum. We diagnosed the patient with synchronous CIN3 and metastatic SCCs of unknown primary in the rectum. In this case, gene analysis was useful to clarify the relationship between CIN3 and SCCs.