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Role of inflammatory markers in polycystic ovaries syndrome: In relation to insulin resistance
Author(s) -
Alissa Eman M.,
Algarni Samiah A.,
Khaffji Azza J.,
Al Mansouri Nisma M.
Publication year - 2021
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.14684
Subject(s) - medicine , insulin resistance , polycystic ovary , anthropometry , body mass index , confounding , endocrinology , obesity , tumor necrosis factor alpha , inflammation , insulin
Objective To evaluate the relationship between plasma levels of the inflammatory markers tumor necrosis factor‐alpha (TNF‐α), C reactive protein (CRP), and interlukin‐6 (IL‐6) with insulin resistance in Saudi women with polycystic ovaries syndrome (PCOS). Methods One hundred eighty Saudi women with and without PCOS, aged 22–38 years, were randomly recruited in this age and body mass index matched case–control study. Clinical assessment, anthropometric measurements, and biochemical parameters were determined for all study participants. Results Levels of TNF‐α, IL‐6, hs‐CRP, insulin, and insulin resistance indices were significantly higher among PCOS group than their age and BMI matched controls ( p < 0.05). Results showed that only QUICK‐I ( β = −0.247, p < 0.0001, 95% CI: −3.009 to −0.977) independently predicted TNF‐α levels after adjustment for potential confounders. Conclusions Elevated plasma levels of TNF‐ α and IL‐6 among PCOS women reflects a state of chronic inflammation with potential implication for insulin resistance, independent of obesity.