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Low placental growth factor levels and high soluble endoglin levels at 26–31 weeks of gestation precede light placenta with and without relatively heavy infant, respectively: A retrospective cohort study
Author(s) -
Hirashima Chikako,
Ohkuchi Akihide,
Sasaki Kemal,
Takahashi Kayo,
Suzuki Hirotada,
Matsubara Shigeki,
Matsuda Yoshio
Publication year - 2021
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.14636
Subject(s) - medicine , placenta , gestation , preeclampsia , obstetrics , placental growth factor , gestational age , birth weight , small for gestational age , pregnancy , risk factor , fetus , vascular endothelial growth factor , biology , genetics , vegf receptors
Abstract Aim Our aim was to examine whether serum levels of placental growth factor (PlGF) and soluble endoglin (sEng) at 19–25 and 26–31 weeks of gestation were associated with the occurrence of the 9‐block categorization of placenta weight (PW) and fetal/placenta ratio (F/P ratio). Methods We performed a retrospective cohort study in 1391 women with singleton pregnancy. Serum levels of PlGF and sEng were measured by enzyme immunosorbent assay. A light placenta was defined as PW ZS < −1.28 SD. Based on the PW (light, normal, and heavy) and F/P ratio (relatively heavy, balanced growth, and relatively small), 9‐block categorization were performed. Multivariable logistic regression analyses were performed. Results Low PlGF at 26–31 weeks was an independent risk factor for the birth of infants belonging to Block A (light placenta and relatively heavy infant), after adjusting for prepregnancy body mass index and serum levels of sEng. High sEng at 26–31 weeks was an independent risk factor for the birth of infants belonging to Block D (light placenta and balanced growth of infant), after adjusting for past history of either preeclampsia or gestational hypertension, high pulsatility index of uterine artery flow velocity waveforms in the second trimester, and serum level of PlGF. Conclusions Low PlGF levels at 26–31 weeks of gestation may precede a light placenta and relatively heavy infant (Block A), and high sEng levels at 26–31 weeks of gestation may precede a light placenta and balanced growth of infant (Block D).