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Trimester‐specific reference intervals of TAT , TM , tPAI‐C and PIC for healthy Chinese pregnant women
Author(s) -
Wu Yufeng,
Qiao Yan,
Zhang Yinmei,
Li Qingsong,
Zhang Wenjing
Publication year - 2021
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.14536
Subject(s) - medicine , pregnancy , andrology , gynecology , biology , genetics
Aim Pregnancy is a hypercoagulability state, the aim of this study was to observe the changes of thrombin–antithrombin complex (TAT), thrombomodulin (TM), tissue plasminogen activator‐inhibitor complex (tPAI‐C) and plasmin‐α2–antiplasmin complex (PIC) during pregnancy and establish trimester‐specific reference intervals for Chinese healthy pregnant women. Methods In total 190 Chinese healthy pregnant women (first trimester 59 cases, second trimester 60 cases and third trimester 71 cases) were recruited in North China. TAT, TM, tPAI‐C and PIC were processed on Sysmex HISCL 5000 automated chemiluminescence immune detection system. Trimester‐specific reference intervals were established with the 2.5th and 97.5th percentile of the distribution. Results The reference intervals for TAT, TM, tPAI‐C, PIC at trimester 1 were 0.40–3.65 ng/mL, 4.85–8.80 TU/mL, 1.75–6.40 ng/mL, 0.25–1.05 μg/mL, respectively. At trimester 2, the reference intervals were 1.65–8.61 ng/mL, 5.70–9.93 TU/mL, 2.91–7.71 ng/mL, 0.33–2.02 μg/mL, respectively. At trimester 3, the reference intervals were 3.16–12.68 ng/mL, 5.50–14.24 TU/mL, 2.70–10.69 ng/mL, 0.24–1.54 μg/mL, respectively. Conclusions The changes of TAT, TM, tPAI‐C, PIC during pregnancy are presented, and trimester‐specific reference intervals for healthy pregnant women are described. The levels of TAT, TM, tPAI‐C were increased gradually from trimester 1 to trimester 3, while the PIC level remains stable during all trimesters.