Premium
Serum fibroblast growth factor 21 level is increased in pre‐eclampsia patients: Association with blood pressure and lipid profile
Author(s) -
Jiang Lin,
Zhou Yang,
Huang Qin
Publication year - 2021
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.14534
Subject(s) - medicine , blood pressure , eclampsia , fgf21 , lipid profile , endocrinology , pregnancy , blood lipids , cholesterol , fibroblast growth factor , biology , genetics , receptor
Background Pre‐eclampsia (PE) is dangerous complication, which leads to adverse pregnancy outcomes. Aims The study was to explore the correlation between serum level of fibroblast growth factor (FGF) 21 and PE. Methods A total of 80 cases were involved in this study containing PE group (49 cases) and control group (31 cases, normal pregnancy). PE group was divided into early‐onset PE (EOPE) and late‐onset PE (LOPE). Serum level of FGF21 and biochemical parameters were measured before delivery. Results Maternal serum FGF21 level was higher in PE especially in EOPE than that in control groups ( P < 0.05). In PE patients, serum FGF21 level was positively correlated with mean arterial pressure, diastolic blood pressure and low‐density lipoprotein cholesterol ( P < 0.05). Levels of FGF21, uric acid and low‐density lipoprotein cholesterol were risk factors for PE. Conclusion Maternal serum FGF21 level in PE particularly in EOPE was higher and was associated with blood pressure and lipid profile.