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A uterine pseudotumor of immunoglobulin G4 ‐related disease
Author(s) -
Senda Yasutaka,
Ikeda Yoshiki,
Tamauchi Satoshi,
Yoshikawa Nobuhisa,
Kikkawa Fumitaka,
Kajiyama Hiroaki
Publication year - 2021
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.14531
Subject(s) - medicine , igg4 related disease , antibody , lymph , lymphoma , disease , pathology , immunology
Abstract Immunoglobulin G4‐related disease (IgG4‐RD) is characterized by systemic lesions presenting as swellings, nodules and wall thickenings. The first‐line therapy is glucocorticoids. This disease is common among middle‐aged and elderly men, and its uterine mass formation is uncommon. We encountered a 39‐year‐old nulliparous woman with an IgG4‐related uterine mass and enlarged pelvic lymph nodes. Complete remission was achieved by fertility‐sparing resection of the uterine mass without glucocorticoids. This case showed that IgG4‐RD can present as a uterine mass and we need to be careful of its diagnostic and therapeutic strategies because an IgG4‐related uterine mass is difficult to distinguish from sarcoma or malignant lymphoma. Our case also demonstrated that IgG4‐related lymphadenopathy could regress spontaneously without complete lymphadenectomy or glucocorticoids when IgG4‐RD does not affect vital organs. A pelvic mass with hyperproteinemia may be a hint to remind us of IgG4‐RD and may trigger a preoperative immunoglobulin test.