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Identify the role of Human Wharton's Jelly Mesenchymal Stem Cells in repairing injured uterine of rat
Author(s) -
Wang Hezhu,
Yang Xiaoqing,
Chen Xiaojing,
Xie Huihui,
Wang Junxia,
Zhang Yuquan
Publication year - 2021
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.14526
Subject(s) - myometrium , medicine , mesenchymal stem cell , andrology , endometrium , saline , uterus , wharton's jelly , stem cell , gynecology , obstetrics , pathology , microbiology and biotechnology , biology
Aim Maternal complications caused by the cesarean delivery inhibit the capability of preserving the uterus and subsequent fertility. However, successful restoration of the incisional scar continuously still remains a challenge. This work was to evaluate the repairing effect of Human Wharton's Jelly Mesenchymal Stem Cells (hWJ‐MSC) on incisional scar of the uterine. Methods Eighteen rats were randomly assigned into two groups and nine for each: one group injected with hWJ‐MSC in phosphate buffer saline (PBS) and the other injected with PBS for comparison. Results With hWJ‐MSC in PBS injected, the uterine endometrium and myometrium with full‐thickness injury were restored and the functionality was greatly improved in comparison with the group only with PBS injected. Conclusion The hWJ‐MSC can repair the injured uterine effectively by promoting the uterine endometrium and myometrium cells proliferation and according to the chi‐square analysis the pregnancy is improved.