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Experimental techniques for the development of a uterus transplantation model in cynomolgus macaques
Author(s) -
Kisu Iori,
Banno Kouji,
Obara Hideaki,
Kato Yojiro,
Yamada Yohei,
Matsubara Kentaro,
Matoba Yusuke,
Adachi Masataka,
Emoto Katsura,
Masugi Yohei,
Saiki Yoko,
Ishigaki Hirohito,
Itagaki Iori,
Kawamoto Ikuo,
Iwatani Chizuru,
Nakagawa Takahiro,
Murase Mitsuru,
Tsuchiya Hideaki,
Nakagawa Kenshi,
Shiina Takashi,
Aoki Daisuke
Publication year - 2020
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.14477
Subject(s) - medicine , transplantation , infertility , gynecology , pregnancy , surgery , biology , genetics
Uterus transplantation (UTx) is now a treatment for women with uterine factor infertility to have a child. However, UTx is still largely at the experimental stage, and many medical issues remain unsolved. Therefore, adequate studies in large animals including non‐human primates are required for validation of these issues. UTx research, especially in non‐human primates, can provide important information for its full establishment in humans due to the anatomical and physiological similarities between the two. We accumulated data from UTx studies using cynomolgus macaques since 2009 and established autologous and allogeneic UTx models which led to deliveries after performing the procedure. In this paper, we summarized key points to develop UTx models in cynomolgus macaques based on our experience. UTx models in non‐human primates can surely contribute new and beneficial knowledge in this field and can be useful for the further development of UTx in humans.