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Nationwide survey of Japanese breast oncology and reproductive endocrinology departments about the impact of breast cancer treatment on fertility
Author(s) -
Yamazaki Rena,
Ono Masanori,
Sugie Tomoharu,
Inokuchi Masafumi,
Ishikawa Satoko,
Iizuka Takashi,
Masumoto Sakiko,
Myojo Subaru,
Uchida Soko,
Horie Akihito,
Matsuzaki Toshiya
Publication year - 2020
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.14469
Subject(s) - medicine , breast cancer , infertility , gynecology , reproductive medicine , oncology , obstetrics , intracytoplasmic sperm injection , reproductive endocrinology , pregnancy , fertility preservation , pregnancy rate , insemination , assisted reproductive technology , fertility , cancer , population , sperm , andrology , hormone , environmental health , biology , genetics
The purpose of this study is to assess the impact of breast cancer treatment on the reproductive potential. We conducted a nationwide survey of breast oncology and reproductive endocrinology and infertility (REI) departments using a questionnaire designed to assess the impact of breast cancer treatment on fertility. We received responses from 312 breast oncology departments (response rate, 31.9%) and 541 REI departments (response rate, 50.9%). The most common method of achieving pregnancy reported by breast oncology departments was natural insemination (69.6%), followed by assisted reproductive technology ( 15.6%) and intrauterine insemination (IUI; 14.8%). The most common method of achieving pregnancy reported by REI departments was conventional in vitro fertilization and/or intracytoplasmic sperm injection (51.0%), followed by natural insemination with or without ovulation induction (40.0%) and IUI (8.0%). The overall pregnancy rate for patients who underwent treatment for infertility at REI departments after breast cancer treatment was 39.0%. Vast patients who experienced breast cancer treatments conceived mainly by natural insemination based on the data from breast oncology departments. On the other hand, 61.0% of the patients who visited REI departments presumably due to infertility by natural insemination did not conceive even by infertility treatments with exclusive knowledge in REI departments.