Premium
Octreotide and lanreotide decrease ovarian ischemia–reperfusion injury in rats by improving oxidative and nitrosative stress
Author(s) -
Kalyoncu Senol,
Yilmaz Bulent,
Demir Mustafa,
Tuncer Meltem,
Bozdag Zehra,
Ince Onur,
Akif Bozdayi Mehmet,
Ulusal Hasan,
Taysi Seyithan
Publication year - 2020
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.14379
Subject(s) - medicine , octreotide , oxidative stress , lanreotide , reperfusion injury , endocrinology , ovarian torsion , somatostatin , ischemia , gastroenterology , urology , surgery , hormone , growth hormone , acromegaly
Aim To investigate the protective effect of octreotide and lanreotide on ovarian damage in experimental ovarian ischemia–reperfusion injury. Methods Fifty‐six rats were separated into seven groups; group 1: sham group, group 2: surgical control group with 3‐h torsion and detorsion, group 3: 0.02 mg/kg s.c. octreotide 30 min before 3‐h torsion, group 4; octreotide just after detorsion for 7 days, group 5: octreotide 30 min before torsion and just after detorsion for 7 days, group 6: single time 20 mg/kg s.c. lanreotide before torsion, group 7: single time lanreotide just after detorsion. Results All histopathological scores except congestion were significantly lower in group 1 than other groups. In addition, hemorrhage (group 2 vs 4: P < 0.05), degeneration (group 2 vs 4: P < 0.05, group 2 vs 5: P < 0.01 and group 2 vs 6: P < 0.05) and total damage score (group 2 vs 4: P < 0.05, group 2 vs 5: P < 0.05, group 2 vs 6: P < 0.05 and group 2 vs 7: P < 0.05) were significantly lower than other groups. Moreover, ovarian tissue total oxidant status and oxidative stress index levels were significantly decreased in groups 5 (both P < 0.05) and 7 (both P < 0.05) when compared to group 2. Furthermore, tissue levels of peroxynitrite were significantly higher in group 2 than groups 1, 3 and 5 (all P < 0.05). Conclusions Octreotide and lanreotide have a protective role against ischemia–reperfusion damage in rat torsion detorsion model by improving histopathological and biochemical findings including tissue levels of total oxidant status, oxidative stress index and peroxynitrite.