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Role of basic fibroblast growth factor in human immunodeficiency virus associated pre‐eclampsia
Author(s) -
Sangany Charline M.,
Moodley Jagidesa,
Onyagunga Onankoy A.,
Naicker Thajasvarie
Publication year - 2020
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.14335
Subject(s) - medicine , trophoblast , fibroblast growth factor , human immunodeficiency virus (hiv) , placental growth factor , immunology , eclampsia , pregnancy , angiogenesis , andrology , endocrinology , obstetrics , fetus , vascular endothelial growth factor , placenta , biology , vegf receptors , genetics , receptor
Aim Cell signaling is vital to ensure successful trophoblast invasion. This study assessed the level of serum basic fibroblast growth factor (FGF‐2) in human immunodeficiency virus (HIV) associated pre‐eclampsia (PE). Methods Using a Bio‐plex Multiplex Immunoassay, FGF‐2 (pg/mL) was analyzed in blood sera collected from 80 pregnant women attending a large regional hospital in Durban, South Africa. Study groups consisted of normotensive and pre‐eclamptic pregnant women stratified according to their HIV status. Data analysis was performed using graphpad prism statistics software, version 5.00. Results In this study, we report a significant decrease of FGF‐2 serum level in pre‐eclamptic compared to normotensive pregnant women groups (25.38 ± 6.69 pg/mL vs 61.79 ± 11.25 pg/mL), irrespective of their HIV status. Similarly, there was a significant decrease in FGF‐2 serum level in HIV positive compared to HIV negative group (33.80 ± 9.62 pg/mL vs 52.15 ± 9.49 pg/mL), irrespective of their pregnancy type. Conclusion This study demonstrates a downregulation of serum FGF‐2 expression in pre‐eclamptic compared to normotensive pregnant women. This decline may be responsible for the defective trophoblast invasion and/or to PE severity. The decline in FGF‐2 expression in HIV infection is probably due to the effect of HIV Tat protein on angiogenesis.