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Association between chronic endometritis and uterine natural killer cell density in women with recurrent miscarriage: clinical implications
Author(s) -
Chen Xiaoyan,
Liu Yingyu,
Zhao Yiwei,
Cheung Wing Ching,
Zhang Tao,
Qi Ruofan,
Chung Jacqueline Pui Wah,
Wang Chi Chiu,
Li Tin Chiu
Publication year - 2020
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.14250
Subject(s) - medicine , recurrent miscarriage , endometritis , andrology , stromal cell , cell , miscarriage , natural killer cell , uterus , cell counting , luteinizing hormone , gynecology , endocrinology , gastroenterology , pregnancy , hormone , biology , cell cycle , cancer , in vitro , cytotoxic t cell , biochemistry , genetics
Aim This aim of this study was to determine the association between uterine natural killer (uNK) cell density and chronic endometritis (CE). Methods Endometrial biopsies from 135 women with recurrent miscarriage were obtained precisely 7 days after luteinizing hormone surge in natural cycles. Endometrial sections were immunostained for CD56 for uNK cells and CD138 for plasma cells, respectively. Uterine NK cell counting was performed according to a standardized protocol and results were expressed as percentage of CD56+ cells/ total stromal cells. High uNK cell density was defined as >4.5% and CE was diagnosed when the plasma cell density > 5.15 cells/ 10 mm 2 . Results The uNK cells density in women with CE (median, 5.1%; range, 3.4–8.8%) was significantly ( P < 0.05) higher than that of those without CE (median, 3.8%; range, 1.2%–7.3%). The prevalence of high uNK cell density in women with CE (11/29, 37.9%) was significantly ( P < 0.05) higher than that of women without CE (8/106, 7.5%). Conclusion To conclude, there was a significant association between high uNK cell density and CE. In women with high uNK cell density, plasma cell should be examined to determine if the underlying cause is associated with CE.