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Proportion of abnormal second 50‐g glucose challenge test in gestational diabetes mellitus screening using the two‐step method in high‐risk pregnant women
Author(s) -
Glaharn Pianpun,
Chumworathayi Bandit,
Kongwattanakul Kiattisak,
Sutthasri Nutwara,
Wiangyot Phimwimon
Publication year - 2020
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.14172
Subject(s) - medicine , gestational diabetes , obstetrics , diabetes mellitus , gestation , pregnancy , gynecology , endocrinology , genetics , biology
Aims To determine the merit of repeating 50‐g glucose challenge test (50‐g GCT) at 24–28 weeks of gestation in high‐risk pregnant women and the prevalence of early‐ and late‐onset gestational diabetes mellitus (GDM). Methods This study was conducted in 1447 pregnant women, 344 of them were at risks for GDM undergoing screening by two‐step method at first visit. Data were not completely collected in 47 women leaving only 297 for analyses. Fifty‐six of 297 pregnant women were diagnosed as early‐onset GDM (18.8%) and the other 241 pregnant women were consequently screened at 24–28 weeks of gestation to identify late‐onset GDM. Screening data were retrieved, including risks, laboratory test results, baseline characteristics and diagnostic outcomes. Proportion of abnormal second 50‐g GCT and the prevalence of late‐onset GDM were estimated. Results The prevalence of late‐onset GDM was 17.8%. Among groups of normal 50‐g GCT, abnormal 50‐g GCT and abnormal 1 oral glucose tolerance test (OGTT) value at first test, the proportions of abnormal 50‐g GCT at second test were 38.3%, 59.5% and 79.3%, and the prevalence of late‐onset GDM among each group were 18.8%, 8.3% and 41.4%, consecutively. This lead to prevalence of GDM in this high‐risk group of 33.3% and overall among 1447 women was 7.9%. Conclusion There were high proportions of abnormal 50‐g GCT at second test in the groups with abnormal 50‐g GCT and abnormal 1 OGTT value at first test (59.5% and 79.3%). Authors suggested doing OGTT without repeating 50‐g GCT in these groups coming at 24–28 weeks of gestation.