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Placental mesenchymal dysplasia with a good outcome: A case report
Author(s) -
Oide Shiho,
Kuwata Tomoyuki,
Wang Liangcheng,
Imai Ken,
Chikazawa Kenro,
Takagi Kenjiro
Publication year - 2019
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.14095
Subject(s) - medicine , placenta , fetus , dysplasia , lesion , mesenchymal stem cell , outcome (game theory) , vegf receptors , obstetrics , bioinformatics , gynecology , pathology , pregnancy , genetics , biology , mathematics , mathematical economics
Placental mesenchymal dysplasia (PMD), characterized by an enlarged and thickened placenta with multiple hypoechoic cystic spaces, frequently leads to a poor infantile/fetal outcome. Here, we describe a case of PMD involving an infant delivered at term with a good outcome. The fetus was male, and the proportion of the PMD lesion to the entire placenta remained constant: the PMD lesion did not enlarge. Given what is known about the pathogenesis of PMD with its association with vascular endothelial growth factor‐D (VEGF‐D) encoded by an X‐linked gene and androgenetic/biparental mosaicism, which is consistent with female dominancy and a poor outcome, we suggest that a male sex of the fetus and non‐progressing PMD may have been associated with this good outcome.