Premium
Abnormal menstruation after radical trachelectomy and its effects on fertility
Author(s) -
Matsuoka Mari,
Taga Atsuko,
Hata Saori,
Yamamoto Rumiko,
Ando Yukiko,
Kozono Yuki,
Tsuji Natsuki,
Sekiyama Kentaro,
Higuchi Toshihiro,
Nagano Tadayoshi
Publication year - 2019
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.14032
Subject(s) - medicine , trachelectomy , menstruation , stage (stratigraphy) , perioperative , univariate analysis , cervical cancer , mann–whitney u test , radical hysterectomy , gynecology , exact test , multivariate analysis , obstetrics , surgery , cancer , paleontology , biology
Aim To evaluate and identify the risk factors for abnormal menstruation after radical trachelectomy. Methods This study included 58 patients who underwent radical trachelectomy at our hospital between April 2005 and January 2018. Patients were divided into groups of those with no change in postoperative menstruation (regular [R] group; n = 46) and those with abnormal menstruation such as amenorrhea or hypomenorrhea (irregular [I] group; n = 12). The perioperative characteristics and fertility of the groups were compared retrospectively. The data were statistically analyzed using Student's t ‐test, Fisher's exact test and Mann–Whitney U test for univariate analysis and logistic regression analysis for multivariate analysis, with the level of statistical significance set at P < 0.05. Results Based on Federation of Gynecology and Obstetrics staging, 54 patients had stage IB1, 2 had stage IB2 and 2 had stage IIA1 cervical cancer. Eight patients received neoadjuvant chemotherapy. Pretreatment tumor size, residual uterine cavity length and neoadjuvant and postoperative chemotherapy use were not significantly different between the groups. Abnormal menstruation was significantly more common in patients with postoperative pelvic infection (R group, 13.0%; I group, 58.3%) and cervical stenosis (R group, 15.2%; I group, 58.3%). Conclusion To maintain healthy menstruation even after radical trachelectomy, it is important to prevent postoperative pelvic infection and cervical stenosis.