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Obstetrical outcomes after first‐trimester chorionic villus sampling in twin pregnancies: A retrospective case–control study
Author(s) -
Kim Mi S.,
Ahn Eunhee,
Lee Soo B.,
Moon Myoung J.,
Kang Sukho
Publication year - 2019
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13993
Subject(s) - medicine , obstetrics , miscarriage , chorionic villus sampling , gestational age , obstetrics and gynaecology , gynecology , neonatal intensive care unit , twin pregnancy , pregnancy , retrospective cohort study , gestation , first trimester , pediatrics , surgery , genetics , biology
Aim Prenatal diagnostic testing by chorionic villus sampling (CVS) is sometimes recommended for women with twin pregnancies. However, few studies have compared the outcomes between twins with CVS and control twins without intervention. This study aimed to compare the obstetrical outcomes of CVS in twin pregnancies and those in non‐intervention twin pregnancies. Methods First‐trimester transabdominal CVS was performed on dichorionic‐diamniotic twins ( n = 54; Group 1) between December 2006 and January 2017 at the Department of Obstetrics and Gynecology at our hospital, and the data were retrospectively analyzed. CVS risks were evaluated by comparing obstetrical outcomes with those of a control population of 155 dichorionic‐diamniotic twins without intervention (Group 2). Results The difference in the overall fetal loss rate (Group 1, 7.4% vs Group 2, 3.9%; P = 0.287) between the two groups was not statistically significant. The miscarriage rate, defined as delivery at <24 gestational weeks, and early preterm delivery, defined as delivery at <34 gestational weeks, were not significant between the groups (miscarriage: Group 1, 5.6% vs Group 2, 3.2%; P = 0.428; early preterm delivery: Group 1, 11.1% vs Group 2, 9.0%; P = 0.788). The mean gestational age at delivery, birth weights and neonatal intensive care unit admission rate were not statistically significant between the groups. Thus, the overall fetal loss rate and obstetrical outcomes of Group 1 were comparable with those of Group 2. Conclusion In conclusion, the overall obstetrical outcomes were not significantly different between twins with CVS and control twins with the advantage of enabling early decision‐making about selective feticide in twins with CVS.