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Antibodies: The major participants in maternal–fetal interaction
Author(s) -
Yang Xin,
Zhang Caiji,
Chen Guozhen,
Sun Chengming,
Li Jinming
Publication year - 2019
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13839
Subject(s) - medicine , antibody , fetus , obstetrics , pregnancy , immunology , genetics , biology
The aim of this study is to improve our understanding of the mechanisms involved in maternal–fetal immune tolerance. We searched the related literatures and overviewed the major antibodies associated with pregnancy and described in details their possible roles in mediating maternal–fetal interactions. Antibodies classified into different types based on their functional or structural characteristics were summarized, including immunoglobulin G, blocking antibody, nonprecipitating asymmetric antibody, antiphospholipid antibody, antitrophoblast antibody and antipaternal antibody. The presence and levels of various circulating antibodies in pregnancy may play a crucial role in the occurrence, development and termination of pregnancy.