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Endocan expression in placenta of women with hypertension
Author(s) -
Chew Bee S.,
Ghazali Razmin,
Othman Hanita,
Ismail Nor A. M.,
Othman Aimi S.,
Laim Nur M. S. T.,
Wong Yin P.,
Tan Geok C.
Publication year - 2019
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13836
Subject(s) - medicine , placenta , fetus , syncytiotrophoblasts , preeclampsia , gestational hypertension , andrology , decidua , decidual cells , obstetrics , gestational age , immunohistochemistry , pregnancy , biology , genetics
Aim The aim of our study was to determine the endocan‐1 expression in placenta of hypertensive women, and its association with maternal and fetal outcomes. Methods This was a cross‐sectional study consisted of 21 pregnant women with hypertension and 23 without hypertension. The gestational age ranged from 28 to 39 weeks (hypertensive) and 32 to 40 weeks (normotensive). The paraffin embedded formalin fixed placenta tissue blocks were retrieved from the pathology archives. Endocan immunohistochemistry was performed on tissue sections of full thickness and maternal surface of the placenta. The endocan expression was determined in fetal endothelial cells, maternal endothelial cells, cytotrophoblasts, syncytiotrophoblasts and decidual cells. The differences in endocan expression in placenta between hypertensive and normotensive subjects were evaluated by Pearson chi‐square test and t ‐test were used in the statistical analysis. Results The endocan expression was significantly higher in fetal endothelial cells ( P < 0.001), maternal endothelial cells ( P = 0.003) and decidual cells ( P < 0.001) in the placenta of women with hypertension. When comparing positive and negative endocan expression in maternal outcomes, endocan was associated with the development of pre‐eclampsia ( P = 0.03). Also, a positive endocan expression was associated with low birthweight ( P = 0.001) and prematurity ( P = 0.005) in the fetal outcomes. Conclusion This study showed endocan is highly expressed in fetal endothelial cells, maternal endothelial cells and decidual cells in placenta of hypertensive women. In addition, its expression was associated with poorer maternal and fetal outcomes. These findings suggest endocan may play an important role in the progression of hypertension in pregnancy.