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Efficacy and safety of motherwort injection add‐on therapy to carboprost tromethamine for prevention of post‐partum blood loss: A meta‐analysis of randomized controlled trials
Author(s) -
Meng Wenbin,
Li Rui,
Zha Nashunbayaer,
E Lihua
Publication year - 2019
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13833
Subject(s) - medicine , adverse effect , confidence interval , randomized controlled trial , post partum , incidence (geometry) , meta analysis , cochrane library , relative risk , obstetrics , anesthesia , pregnancy , genetics , physics , optics , biology
Abstract Motherwort (YiMuCao), a traditional Chinese herb, has been shown beneficial effects for women's diseases. This meta‐analysis aimed to evaluate the efficacy and safety of motherwort injection add‐on therapy to carboprost tromethamine for prevention of post‐partum blood loss. A systematic literature search was conducted in PubMed, Embase, Cochrane Library, CNKI, VIP and Wanfang from their inception to December 2017. Randomized controlled trials that determined the add‐on effects of motherwort injection to carboprost for prevention of post‐partum blood loss were eligible. Pooled risk ratio (RR) and mean difference (MD) with 95% confidence interval (CI) were used to summarize the effect sizes. Eight trials including 1276 pregnant women fulfilled the inclusion criteria. Prophylactic use of motherwort injection add‐on therapy significantly reduced the post‐partum 2 h (MD −127.5 mL; 95% CI −149.13 to −105.88) and 24 h (MD −146.85 mL; 95% CI −179.77 to −113.94) blood loss and incidence of post‐partum hemorrhage (RR 0.28; 95% CI 0.17–0.45) than carboprost. Moreover, adjunctive treatment with motherwort injection significantly decreased the length of the third stage of labor (MD −3.41 min; 95% CI −4.33 to −2.49) and duration of lochia (MD −7.13 days; 95% CI −8.49 to −5.76). There was no statistical significant difference in the incidence of adverse events (RR 0.76; 95% CI 0.50–1.16). Prophylactic use of motherwort injection add‐on therapy to carboprost tromethamine could reduce post‐partum blood loss. However, more well‐designed trials are necessary to confirm the findings of this study due to the methodological flaws of the included trials.