Premium
Effects of leuprorelin for the treatment of recurrent gynecological cancer by assessment including self‐administered quality‐of‐life questionnaire
Author(s) -
Tsubamoto Hiroshi,
Ueda Tomoko,
Inoue Kayo,
IsonoNakata Roze,
Saeki Shinichiro,
Kato Yu,
Shibahara Hiroaki
Publication year - 2019
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13784
Subject(s) - medicine , leuprorelin , quality of life (healthcare) , endometrial cancer , ovarian cancer , cancer , disease , gynecology , chemotherapy , oncology , hormone , gonadotropin releasing hormone , nursing , luteinizing hormone
Aim To investigate the effects of leuprorelin using a self‐administered quality‐of‐life (QOL) questionnaire in patients with recurrent gynecological cancer. Methods Records of patients who received 3.75 mg leuprorelin every 4 weeks for the treatment of recurrent gynecological cancer were retrospectively reviewed. The physical domain of the QOL questionnaire, Care Notebook, was used to assess physical symptoms. Symptom deterioration was defined as a ≥10‐point increase in baseline score; otherwise, symptoms were defined as controlled. Radiological and serological responses were evaluated according to the 2011 Gynecological Cancer Intergroup criteria. Results From 2007 to 2015, 25 patients were administered leuprorelin for the treatment of epithelial ovarian cancer, granulosa cell tumor, endometrial cancer, endometrial stromal sarcoma and clear cell cervical cancer (in 13, 3, 6, 2 and 1 patients, respectively). Twenty patients had received a median of three lines (range 1–12 lines) of chemotherapy. Ten patients had progressive disease during their previous round of chemotherapy. Twenty patients completed the questionnaire every 4 weeks. Following leuprorelin treatment for 8 weeks, the symptom and disease control rates were 65% (13/20) and 44% (11/25), respectively. Two patients, one each with granulosa cell tumor and endometrial cancer, had stable disease at 6 months. Among the 20 patients who completed the QOL questionnaire, symptom control and disease control at 8 weeks showed a significant correlation ( P = 0.016). Conclusion Leuprorelin had minimal anticancer activity. The physical domain of the QOL questionnaire could be used to assess effects of hormonal treatment.