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Primary breast cancer of the vulva: A case report and literature review
Author(s) -
AlMansouri Loma,
Poursoltan Pirooz,
Simons Mary,
Muljono Anita,
Boyages John
Publication year - 2018
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13778
Subject(s) - medicine , mammaglobin , vulva , breast cancer , apocrine , cytokeratin , biopsy , hormonal therapy , cancer , radiation therapy , oncology , pathology , gynecology , immunohistochemistry
An elderly lady presented with a 2‐year history of intermittent vaginal bleeding and later the development of a vulvovaginal mass. A core biopsy histology specimen from the mass and the left inguinal lymph node was suggestive of metastatic adenocarcinoma of breast origin. No breast lesion was detected on mammography, and axillary nodes were negative. The histopathologic features and the expression of GATA3, cytokeratin (CK)7, mammaglobin staining and estrogen and progesterone receptors led to a diagnosis of breast cancer originating from the ectopic mammary tissue in the vulva. Given the rarity of these lesions, and the lack of standard treatment guidelines, the management of the patient was extrapolated from the established breast cancer treatment guidelines. Radiotherapy and chemotherapy followed by hormone therapy with aromatase inhibitor were administered to this patient in the metastatic setting with good palliation.

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