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A fetus coexisting with a complete hydatidiform mole with trisomy 9 of maternal origin
Author(s) -
Kan Anita Sik Yau,
Lau Elizabeth Tak Kwong,
So Chun Hong,
Chan Wan Pang,
Wong Wing Cheuk,
Lee Kam Cheong,
Pertile Mark D.,
Tang Mary Hoi Yin
Publication year - 2018
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13598
Subject(s) - fetus , trisomy , genotyping , medicine , partial hydatidiform mole , mole , obstetrics , aneuploidy , immunohistochemistry , pregnancy , gynecology , pathology , placenta , genetics , biology , genotype , gene , chromosome
A complete hydatidiform mole (CHM) coexisting with a viable fetus is a rare finding in pregnancies. Accurate diagnosis often relies on ultrasonographic, histopathological and molecular techniques in the definite diagnosis. To the best of our knowledge, a liveborn fetus coexisting with CHM with trisomy 9 has not been described. The use of molecular genotyping and immunohistochemical laboratory investigations enabled the CHM to be fully characterized. Postzygotic diploidization of a triploid conception arising from dispermy is the proposed mechanism of its formation.
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