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Association of body mass index and weight gain patterns with albumin excretion in pregnancy
Author(s) -
Tulmaç Özlem B.,
Dağ Zeynep Ö.,
Erdoğan Funda,
Sayan Cemile D.,
Sağsöz Nevin
Publication year - 2018
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13548
Subject(s) - medicine , weight gain , body mass index , overweight , pregnancy , gestation , obesity , endocrinology , creatinine , excretion , obstetrics , body weight , biology , genetics
Aim We examined body mass index (BMI) and gestational weight gain (GWG) patterns of pregnant women and investigated the impact of these factors on the urinary albumin‐creatinine ratio (ACR) during pregnancy. Methods The data of 163 women whose basal BMI and ACR were measured during the first trimester were used in this study. Body weight alone between 12–16 weeks and body weight together with ACR after 37 weeks of gestation were measured. Results Overall, 46% of women were overweight or obese, 60.7% had excessive weight gain and 16.6% had inadequate weight gain. Only 22.7% of women gained weight within the recommended range. There was no difference in weight gain patterns with respect to BMI. ACR during the third trimester was significantly higher than during the first trimester (7.08 [0.00–1180.90] mg/g vs 4.73 [0.00–275.00] mg/g, respectively; P = 0.001). The ACR of obese women was higher than in normal weight subjects during the third trimester (16.79 mg/g [0.01–1180.90] vs 8.07 mg/g [0.10–402.14] respectively; adjusted P = 0.015). Both ACR change and third trimester ACR were weakly but significantly correlated with basal BMI (r: 0.228 P : 0.003 and r: 0.301 P < 0.001, respectively) but not with GWG or GWG rate. Basal BMI was not associated with first‐trimester ACR. Conclusion Obesity is associated with an increase in urinary albumin excretion during the course of pregnancy. Distinction of this relationship during pregnancy offers an opportunity for further research on pathophysiological mechanisms. The alarmingly high rate of non‐compliance with IOM guidelines in pregnant women is a concern. Prompt measures for counseling of women before and during pregnancy in order to maintain healthy weight are needed.