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Influence of perinatal low‐dose acetylsalicylic acid therapy on fetal hemodynamics evaluated by determining the acceleration‐time/ejection‐time ratio in the ductus arteriosus
Author(s) -
Miyazaki Miwa,
Kuwabara Yoshimitsu,
Takeshita Toshiyuki
Publication year - 2018
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13465
Subject(s) - medicine , ductus arteriosus , gestational age , hemodynamics , acceleration time , cardiology , fetus , doppler echocardiography , pregnancy , diastole , anesthesia , blood pressure , acceleration , genetics , physics , classical mechanics , biology
Aim Acceleration‐time/ejection‐time ratio (At/Et ratio) of Doppler waveform is an established hemodynamic parameters that reflect proximal stenosis. Using this parameter, we evaluated whether perinatal low‐dose acetylsalicylic acid (ASA) therapy could alter hemodynamics in the ductus arteriosus. Methods Pulse Doppler measurements of the fetal ductus arteriosus were performed longitudinally from 20 to 37 gestational weeks in 106 healthy pregnant women (controls) and 65 pregnant women taking daily low‐dose ASA (80 or 100 mg/day) because of a history of recurrent pregnancy loss. The At/Et ratio, pulsatility index (PI), and peak systolic velocity were evaluated and statistically analyzed. Results The At/Et ratio significantly increased with gestational age in both the ASA group ( r = 0.54) and the control group ( r = 0.35), while the PI did not. Median peak systolic velocities also increased with gestational age in both the ASA group ( r = 0.39) and the control group ( r = 0.31). No significant differences in At/Et ratio, PI, or peak systolic velocity were observed between the ASA group and the control group. Conclusion Administration of low‐dose ASA during pregnancy did not appear to alter hemodynamics in the fetal ductus arteriosus.