Premium
Genetic markers for inherited thrombophilia are associated with fetal growth retardation in the population of Central Russia
Author(s) -
Reshetnikov Evgeny,
Zarudskaya Oksana,
Polonikov Alexey,
Bushueva Olga,
Orlova Valentina,
Krikun Evgeny,
Dvornyk Volodymyr,
Churnosov Mikhail
Publication year - 2017
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13329
Subject(s) - medicine , genotype , thrombophilia , allele , odds ratio , fibrinogen , polymorphism (computer science) , population , genetics , gene , biology , thrombosis , environmental health
Aim The aim of this study was to examine the role of hereditary thrombophilia in the development of fetal growth retardation (FGR) in the population of Central Russia. Methods The case–control study sample included 497 women in the third trimester of pregnancy recruited during 2009–2013. The participants were enrolled into two groups: patients with FGR ( n = 250) and controls without FGR ( n = 247). The participants were genotyped for four genetic markers of hereditary thrombophilia: factor V Leiden ( G > A FV , rs6025), prothrombin ( G > A FII , rs1799963), factor VII ( G > A FVII , rs6046), and fibrinogen ( G > A FI , rs1800790). Results The genetic factors for an increased risk of FGR were allele G of rs6046 (odds ratio [OR] = 2.34) and genotype GG of rs6046 (OR = 2.64), whereas genotype GA of rs6046 had the protective value (OR = 0.42). A combination of alleles G of rs1799963, A of rs6046, and G of rs1800790 (OR = 0.31) reduces the risk of FGR. Conclusion Polymorphism rs6046 of the FVII gene is associated with the development of FGR.