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Effect of the injectable contraceptive depot‐medroxyprogesterone acetate on coagulation parameters in new users
Author(s) -
MelhadoKimura Vaneska,
Bizzacchi Joyce Maria Annichino,
Quaino Susan Kelly Picoli,
Montalvao Silmara,
Bahamondes Luis,
Fernandes Arlete
Publication year - 2017
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13306
Subject(s) - medicine , medroxyprogesterone acetate , partial thromboplastin time , medroxyprogesterone , body mass index , antithrombin , coagulation , thrombin generation , population , thrombin time , gynecology , obstetrics , thrombin , heparin , platelet , estrogen , environmental health
Aim The aim of this study was to assess the effects of the injectable depot‐medroxyprogesterone acetate (DMPA) contraceptive on selected blood coagulation parameters in young, healthy new users. Methods The prospective study included 39 healthy women aged 20–39 years, with a body mass index (BMI; kg/m 2 ) < 30, who were never users of DMPA, and who opted to use DMPA (21 women) or a copper intrauterine device (IUD; 18 women). The women in the two groups were matched for age (±1 year) and BMI (±1). Blood samples were obtained from all participants at baseline and at 6 and 12 months. Activated partial thromboplastin time, D‐dimer, protein C, antithrombin, protein S, and thrombin generation test (lag time, endogenous thrombin potential, time to peak, and velocity index of thrombin generation) were analyzed. Repeated‐measures analysis of variance was used to compare the groups. Results There were no significant differences between the groups at baseline with respect to any of the parameters evaluated; however, in the DMPA group, D‐dimer levels were lower and the time to peak thrombin generation was longer than in the IUD group at 12 months of evaluation. Conclusion Lower D‐dimer and longer time to peak thrombin generation in new users of DMPA suggest a positive profile against hypercoagulability.