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Comparison of thyroid function tests and blood count in pregnant women with versus without gestational diabetes mellitus
Author(s) -
Gorar Suheyla,
Abau Gul Babacan,
Uysal Aysel,
Erol Onur,
Unal Aysun,
Uyar Seyit,
Cekin Ayhan Hilmi
Publication year - 2017
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13280
Subject(s) - medicine , gestational diabetes , confidence interval , odds ratio , thyroid function , obstetrics , diabetes mellitus , thyroid stimulating hormone , thyroid function tests , pregnancy , thyroid , gynecology , endocrinology , gestation , genetics , biology
Aim The aim of this study was to compare thyroid function and complete blood count parameters in pregnant women with versus without gestational diabetes mellitus (GDM). Methods A total of 269 pregnant women patients with ( n = 110, GDM group) or without ( n = 159, non‐GDM group) GDM were included in this study. Data on age, rate of cesarean section, birthweight of neonate, hemogram, and thyroid function tests were collected. Multivariate analysis was performed to determine factors predicting increased risk of GDM. Results Rate of cesarean section (70.9 vs 57.2%, P = 0.022), median (max–min) age (33.0 [26.0] vs 26.0 [20.0] years, P < 0.001), platelet count (246.7 ± 68.3 vs 227.8 ± 64.2 ×10 3 /μL, P = 0.021) and thyroid‐stimulating hormone (1.3 [97.6] vs 1.0 [4.1] μIU/mL, P = 0.028) were significantly higher in the GDM than in the non‐GDM group; whereas mean platelet volume (10.4 [5.3] vs 10.6 [5.6] fL, P = 0.031) and free triiodothyronine (FT3) (2.9 [3.6] vs 3.1 [3.0] pg/mL, P < 0.001) levels were significantly lower in the GDM than in the non‐GDM group. Older age (odds ratio, 1.281; 95% confidence interval, 1.182–1.389, P < 0.001) and lower FT3 levels (odds ratio, 0.295; 95% confidence interval, 0.149–0.586, P < 0.001) were independently associated with increased risk of GDM. Conclusion Our findings revealed that lower FT3 levels and older age predict the likelihood of developing GDM in euthyroid pregnant women, with no influence of other thyroid hormones or blood counts on the risk of GDM.