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Assessment of oxidative stress markers in cord blood of newborns to patients with oxytocin‐induced labor
Author(s) -
Karaçor Talip,
Sak Sibel,
Başaranoğlu Serdar,
Peker Nurullah,
Ağaçayak Elif,
Sak Muhammet Erdal,
Turgut Abdulkadir,
Evsen Mehmet Sıddık,
Evliyaoğlu Osman,
Gül Talip
Publication year - 2017
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13263
Subject(s) - medicine , malondialdehyde , oxytocin , oxidative stress , obstetrics , apgar score , cord blood , asymmetric dimethylarginine , pregnancy , obstetrics and gynaecology , fetus , physiology , anesthesia , arginine , biochemistry , chemistry , amino acid , biology , genetics
Abstract Aim We aimed to measure the extent of oxidative stress experienced during labor by the neonates of pregnant women undergoing induced or spontaneous birth and to compare the effects of induced labor on fetal well‐being. Methods Sixty‐four healthy pregnant women referring to the Department of Gynecology and Obstetrics, Dicle University Medical Faculty between October 2010 and May 2011 were included in this comparative study. Pregnant women undergoing induced labor by oxytocin were group 1 and those without labor induction were group 2. Post‐partum Apgar score was calculated at 1 and 5 min and measurements of weight and height of the neonates were carried out. After the fetal cord was clamped, 5 cm 3 blood was drawn into a plain tube without anticoagulant. The samples were centrifuged at 5000 r.p.m. for 5 min. Separated sera were transferred to Eppendorf tubes and were stored at −80 C° until the analysis time. Results The complete blood counts and biochemistry results indicated that there were no statistically significant differences in regards to diseases between the two groups. Nitric oxide and asymmetrical dimethylarginine values of the two groups were not significantly different; however, there were statistically significant differences in the malondialdehyde, paraoxonase, total antioxidative status, and total oxidative status values of the two groups (respectively, P = 0.005, P = 0.006, P = 0.008, and P = 0.007). Conclusion We observed that oxytocin‐induced labor increases stress markers but does not affect Apgar scores. Oxidative stress in pregnant women may trigger antioxidative mechanisms. Prospective studies in larger cohorts are needed to better understand the impact of oxytocin‐induced labor on pregnant women and neonates.