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FDG‐PET‐positive ovarian thecoma with GLUT5 expression: Five cases
Author(s) -
Bono Yukiko,
Mizumoto Yasunari,
Nakamura Mitsuhiro,
Iwadare Jyunpei,
Obata Takeshi,
Fujiwara Hiroshi
Publication year - 2017
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13243
Subject(s) - medicine , positron emission tomography , standardized uptake value , magnetic resonance imaging , ovarian cancer , immunohistochemistry , fluorodeoxyglucose , nuclear medicine , radiology , positron emission , cancer , pathology
Positron emission tomography (PET) with fluorodeoxyglucose F18 ( 18 F‐FDG) is useful for detecting malignancies, but benign lesions occasionally have false‐positive 18 F‐FDG uptake. Here, we report the cases of five postmenopausal women with solid ovarian tumors suspected to be ovarian cancer on magnetic resonance imaging and 18 F‐FDG uptake. Mean age of the five patients was 57 years (range, 53–65 years). Average early standardized uptake value (SUV) of 18 F‐FDG was 5.76 (range, 2.2–12.0) and delayed SUV was 6.56 (range, 2.4–13.8). In all five patients, frozen section diagnosis at surgery was thecoma, and bilateral salpingo‐oophorectomy was performed. On immunohistochemistry, immunoreactive glucose transporter 5 (GLUT5) expression was detected in thecoma tissues. This case shows that thecoma sometimes has positive 18 F‐FDG uptake on positron emission tomography–computed tomography (PET‐CT), indicating the need for caution regarding false‐positive PET‐CT in patients with benign solid ovarian tumor.