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Influence of Behçet's disease on first and second trimester serum screening markers
Author(s) -
Yılmaz Zehra Vural,
Türkmen Gülenay Gençosmanoğlu,
Yılmaz Elif,
Dağlar Korkut,
Kırbaş Ayşe,
Sanhal Cem,
Yücel Aykan,
Uygur Dilek
Publication year - 2017
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13237
Subject(s) - medicine , obstetrics , pregnancy , human chorionic gonadotropin , gestational age , body mass index , aneuploidy , birth weight , gynecology , low birth weight , hormone , biochemistry , chemistry , genetics , gene , chromosome , biology
Aim Behçet's disease (BD) is a rare and multisystemic vasculitis disease. In this study, we investigated whether BD had any effect on the biochemical components of first and second trimester aneuploidy screening tests. Methods A case–control retrospective study was conducted with 32 pregnant women with BD and 60 healthy pregnant women as controls. All pregnant womens’ first trimester maternal serum pregnancy‐associated plasma protein‐A, free β ‐human chorionic gonadotropin and second trimester serum alpha‐fetoprotein, unconjugated estriol and total human chorionic gonadotropin levels were examined from medical records. First and second serum screening markers were compared between pregnancies with BD and without. Results There was no difference in age, body mass index and obstetric history between the groups. No significant difference was observed between the groups in terms of first and second trimester serum screening test results in the absence of aneuploidy or neural tube defect. Gestational age at birth, birth weight and neonatal intensive care admission rate were also similar between the groups. Conclusion Both first and second serum screening tests for Down syndrome may be recommended to pregnant women with BD without the need to readjust these markers. Pregnancy with BD was not associated with adverse perinatal outcome with respect to gestational age at birth or birth weight.