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Hypertension and early menopause after the use of assisted reproductive technologies in women aged 43 years or older: Long‐term follow‐up study
Author(s) -
Rosato Elena,
Perrone Giuseppina,
Capri Oriana,
Galoppi Paola,
Candelieri Miriam,
Marcoccia Eleonora,
Schiavi Michele Carlo,
Zannini Ilaria,
Brunelli Roberto
Publication year - 2016
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13141
Subject(s) - medicine , menopause , blood pressure , body mass index , surgical menopause , diabetes mellitus , gynecology , obstetrics , endocrinology
Aim The aim of this study was to investigate the long‐term consequences to women's health and the onset of menopause in healthy women of advanced reproductive age who conceived by assisted reproductive technologies (ART). Methods Healthy women who conceived by ART (72) and controls (80) were selected among 320 women ≥ 43 years, who delivered between January 2010 and December 2011 in the Department of Gynecological and Obstetrical Sciences and Urological Sciences of “Sapienza” University of Rome. Body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), and presence of hypertension and diabetes were analyzed at three days, six months, and three years after delivery. The onset of menopause was analyzed after three years. Results In the ART group, SBP, DBP and hypertension were higher at three days, six months, and three years after delivery. Menopausal age was significantly lower. Conclusion The impact of ART in healthy women of advanced reproductive age in the years after delivery is not limited to the possible development of cardiovascular risk factors, such as hypertension, but can also influence the age of onset of menopause.