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Rapid malignant transformation of low‐grade astrocytoma in a pregnant woman
Author(s) -
Hanada Tomoko,
Rahayu Tri Uji,
Yamahata Hitoshi,
Hirano Hirofumi,
Yoshioka Takako,
Arita Kazunori
Publication year - 2016
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13072
Subject(s) - medicine , malignant transformation , astrocytoma , transformation (genetics) , obstetrics , oncology , pathology , cancer research , glioma , genetics , biology , gene
We report rapid malignant transformation of diffuse astrocytoma to glioblastoma during pregnancy in a young woman. A 21‐year‐old woman was found to have a non‐enhancing right frontal lesion, supposed to be a low‐grade astrocytoma according to magnetic resonance imaging (MRI) studied for chronic headache. Due to the absence of clinical symptoms, the patient refused further investigations and delivered a baby and then became pregnant with a second baby. At first, she refused the biopsy because she was afraid, although the size of the lesion on MRI was increasing; however, due to repeated persuasion, she underwent a biopsy during the 4th month of her second gestation, with a result of diffuse astrocytoma (WHO grade II). At 1 month after the second delivery and 6 months after the biopsy, MRI revealed further enlargement of the tumor and a heterogeneous kenhancement effect. A gross tumor removal was carried out, and the tumor was histologically diagnosed as glioblastoma (WHO grade IV). This is the quickest ever malignant transformation of diffuse astrocytoma during pregnancy in the published reports.