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Invasive cervical cancer accompanied by IgG4‐related disease
Author(s) -
Mizuno Rin,
Yamanishi Yukio,
Uda Satoko,
Terashima Tsuyoshi,
Higashi Tatsuya,
Higuchi Toshihiro
Publication year - 2016
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13030
Subject(s) - medicine , malignancy , radiology , magnetic resonance imaging , cervical cancer , lymph node , supraclavicular lymph nodes , cancer , igg4 related disease , mediastinum , disease , pathology , cervix , breast cancer
IgG4‐related disease (IgG4‐RD) is a systemic disease that affects multiple organs and generates nodules or thickening. Discriminating these diseases from malignancy is important because glucocorticoid treatment is effective for patients with IgG4‐RD. Coexistence of IgG4‐RD with various malignant diseases has been reported, but there are few reports with regard to gynecologic malignant diseases. We encountered a case of invasive cervical cancer stage IIB accompanied by IgG4‐RD. The patient was a 46‐year‐old woman. On pelvic magnetic resonance imaging, fluorodeoxyglucose‐positron emission tomography and computed tomography, systemic multiple lymph node swelling was seen, including in the neck and the mediastinum in addition to uterine cervix. Diagnosis (and hence, appropriate treatment choice) was achieved on pathology of the submandibular gland and uterus, and analysis of serum IgG4. IgG4‐RD should be suspected in patients presenting with malignancy and unusual multiple lymph node swelling.