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Sclerosing angiomatoid nodular transformation of the spleen during pregnancy: Diagnostic challenges and clinical management
Author(s) -
Corrado Giacomo,
Tabanelli Valentina,
Biffi Roberto,
Petralia Giuseppe,
Tinelli Andrea,
Peccatori Fedro A
Publication year - 2016
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13008
Subject(s) - medicine , gestation , pregnancy , malignancy , splenectomy , spleen , differential diagnosis , radiology , lesion , fetus , pathology , genetics , biology
We report the first case of sclerosing angiomatoid nodular transformation (SANT) of the spleen diagnosed during pregnancy, discussing differential diagnosis, immunohistochemical profile and treatment. A G2P1 37‐year‐old woman presented during the 19th week of gestation because of pruritus at lower limbs. To exclude cholestasis, an abdominal ultrasound and whole body magnetic resonance were performed and a single solid lesion with intrinsic vascularization was identified. Therefore, at 22 weeks gestation, after normal fetal assessment, the patient was referred for a splenectomy. No further treatment was suggested and the patient gave birth at 42 weeks gestation with a spontaneous delivery. Distinguishing SANT from other vascular neoplasms of the spleen during pregnancy is a difficult task. Surgical excision should be performed to exclude malignancy and to resolve symptoms, if present.