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Prenatal assessment of pulmonary maturity on 3‐D ultrasound
Author(s) -
Wang ShaSha,
Tian XueYe,
Yan HongWei,
Yuan Ting,
Zheng XiaoYe,
Han Zhen
Publication year - 2016
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13006
Subject(s) - medicine , prenatal ultrasound , maturity (psychological) , ultrasound , obstetrics , prenatal diagnosis , pregnancy , radiology , fetus , genetics , biology , psychology , developmental psychology
Aim The aim of this study was to assess the feasibility and accuracy of 3‐D ultrasound indices to evaluate fetal lung maturity, and to establish a normal reference for fetal lung volume (FLV) and fetal lung‐to‐liver intensity ratio (FLLIR) in a Chinese population. Methods A total of 1022 pregnant women with singleton pregnancy were prospectively studied between June 2008 to June 2011. Ultrasound examination was performed. The breathing‐related nasal fluid flow (BRNFF) spectrum, FLV, pulmonary artery blood flow parameters, and echo intensity of the lung were calculated. Phosphoglycerides in the amniotic fluid were measured on thin layer chromatography. Results FLLIR and FLV were positively and linearly correlated with gestational age (F = 0.915, 0.846). Indicators of fetal lung maturity included FLLIR >1.1, FLV >50 mL, and regular BRNFF spectrum, with positive likelihood ratios of 12.28, 11.78, and 11.63, independently. Conclusion Ultrasound indices, including FLLIR, FLV and BRNFF may serve as useful alternatives to amniotic fluid phospholipids in analyzing fetal lung maturity in Chinese patients.